| CatalogCode: | NB300-338 |
| ProductName: | LDL Receptor Antibody |
| Product Description: | Chicken Polyclonal anti-LDL Receptor |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant fragment, corresponding to amino acids 29-205 of Human LDL Receptor. |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken antisera. |
| Uses: | This antibody can be used in Immunohistochemistry and Western Blot. In Western Blot a 160kDa band is seen.*Optimal dilutions should be determined by the end user. |
| Localization: | Plasma membrane |
| Control: | LDLR transfected 293 cell lysate. |
| Background: | LDL-R binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Defects in LDLR are the cause of familial hypercholesterolemia (FH) [MIM:143890]; a common autosomal semi-dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). |
| ProductRef: | 1. Qian, Yue-Wei., et al. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. Journal of Lipid Research. 2007. 2. Morral, Nuria., et al. Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver. Journal of Lipid research. 2007. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 295 |
| NovusRef: | 1. Qu, Shen., et al. Effects of apoA-V and VLDL metaobolism in APOC3 transgenic mice. Journal of Lipid Research. 2007. |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Low-density lipoprotein receptor antibody |
| ProteinTarget: | LDL Receptor antibody |
| PackageSize: | 0.05 mg |
| GeneralRef: | Agnello V et al. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci U S A 96:12766-71 (1999). |