| Catalog Code: | NB300-308 |
| Product Type: | Primary Antibody |
| Product Name: | Amyloid Precursor Protein Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 351 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-Amyloid Precursor Protein |
| Cross Reactivity: | Dog, human, mouse, non-human primates and rat based on 100% antigen sequence homology. |
| Species Summary: | Ca, Hu, Mu, Mk, Rt |
| Background: | A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD). The phosphorylation APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid pept |
| Alternate Names: | anti-AAA antibody, anti-ABETA antibody, anti-ABPP antibody, anti-AD1 antibody, anti-Alzheimer disease antibody, anti-Amyloid beta A4 protein precursor isoform b antibody, anti-Amyloid beta A4 protein precursor isoform c antibody, anti-Amyloid beta-peptide |
| Immunogen: | Peptide corresponding to amino acid residues from the C-terminal region of rat APP. |
| Specificity: | Specific for ~115k APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen. |
| Packaging: | 0.1 ml in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots. |
| Package Size: | 0.1 ml |
| Uses: | This antibody can be used for Western blot. Suggested Starting Dilution:* WB: 1:1,000 *The investigator should determine the optimal working dilution for a specific application |
| Application Summary: | WB |
| General References: | 1. Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361. 2. Kamenetz F, Tomita T, Hsie |
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