| CatalogCode: | NB300-302 |
| ProductName: | GluR2/3 Antibody |
| Product Description: | Rabbit Polyclonal anti-GluR2/3 |
| Clonality: | Polyclonal |
| Immunogen: | Peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3. |
| Specificity: | Specific for the ~100k GluR2/3 protein. |
| CrossReactivity: | Human, mouse and rat based on 100% antigen sequence homology. |
| Packaging: | 0.1 ml in 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots. |
| Uses: | The investigator should determine the optimal working dilution for a specific application. |
| Localization: | Cell Membrane; multi-pass membrane protein. |
| Background: | The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Host_Name: | Rabbit |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | Anti-AMPA selective glutamate receptor 2 antibody; Anti-AMPA selective glutamate receptor 3 antibody; Anti-Glur 2 antibody; Anti-GluR 3 antibody; Anti-GluR B antibody; Anti-GluR C antibody; Anti-GluR K2 antibody; Anti-GluR K3 antibody; Anti-Glur2 antibody; Anti-GLUR3 antibody; Anti-GLURB antibody; Anti-GLURC antibody; Anti-GLUTAMATE RECEPTOR 2 antibody; Anti-GLUTAMATE RECEPTOR 3 antibody; Anti-Glutamate receptor ionotropic AMPA 2 antibody; Anti-Glutamate receptor ionotropic AMPA 3 antibody; Anti-glutamate receptor metabotropic type 3 antibody; Anti-GPRC1C antibody; Anti-GRIA2 antibody; Anti-GRM3 antibody; Anti-HBGR2 antibody; Anti-Metabotropic glutamate receptor 3 precursor antibody; Anti-MGR3 antibody |
| ProteinTarget: | GluR2/3 Antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755. 2. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108. 3. Keinänen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560. |