| CatalogCode: | | NB300-301 |
| ProductName: | | GluR2 Antibody |
| Product Description: | | Rabbit Polyclonal anti-GluR2 |
| Clonality: | | Polyclonal |
| Immunogen: | | Peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH). |
| Specificity: | | Specific for the ~100k GluR2 protein. |
| CrossReactivity: | | Human, mouse and rat based on 100% antigen sequence homology. |
| Packaging: | | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | | This antibody can be used for Western blot.*The investigator should determine the optimal working dilution for a specific application. |
| Background: | | The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D- aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by -amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Host_Name: | | Rabbit |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu, Mu, Rt |
| ALTnames: | | anti-Gprc1b antibody, anti-Grm2 antibody, anti-AMPA selective glutamate receptor 2 antibody, anti-GluR B antibody, anti-GluR K2 antibody, anti-Glutamate receptor 2 antibody, anti-Glutamate receptor ionotropic AMPA 2 antibody, anti-Gria2 antibody |
| ProteinTarget: | | GluR2 Antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755. 2. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108. 3. Keinänen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560. |
| more information: | | company product webpage |