| Catalog Code: | NB300-277 |
| Product Type: | Primary Antibody |
| Product Name: | Lipoxygenase Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 240 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-Lipoxygenase [Ser523] |
| Phosphorylated: | Ser523 |
| Cross Reactivity: | Recognizes human and rat forms of 5-LO. Not tested in other species. |
| Species Summary: | Hu, Rt |
| Background: | The enzyme 5-lipoxygenase (5-LO) play a key role in regulating the production of leukotrienes (LTs) (Funk, 2001). Overproduction of LTs contribute to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994) fib |
| Alternate Names: | anti-5-delta-lipoxygenase antibody, anti-5-lipoxygenase antibody, anti-Arachidonic 5-lipoxygenase antibody, anti-Arachidonic acid 5-lipoxygenase antibody, anti-C-5-lipoxygenase antibody, anti-Delta(5)-lipoxygenase antibody, anti-Leukotriene-A(4) synthase |
| Immunogen: | Phosphopeptide corresponding to amino acids residues surrounding the phospho Ser523 of human 5-Lipoxgenase (5-LO). |
| Specificity: | Specific for the ~80k 5-LO phosphorylated at Ser523 in Western blots of rat hippocampal lysate. |
| Buffer: | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% glycerol |
| Packaging: | 0.1 ml affinity purified rabbit serum (affinity purification via sequential chromatography on phospho- and non-phosphopeptide affinity columns). *Adequate amount of material to conduct 10-mini Western Blots. |
| Package Size: | 0.1 ml |
| Uses: | This antibody has been tested in Western blot analysis. *Recommended starting dilution: Western blot - 1:1,000 *The investigator should determine the optimal working dilution for a specific application. |
| Application Summary: | WB |
| General References: | 1. Drazen JM, Lilly CM, Sperling R, Rubin P, Israel E (1994) Role of cysteinyl leukotrienes in spontaneous asthmatic responses. Adv. Prostaglandin Thromboxane Leukot Res 22:251-262. 2. Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, Lusis AJ, Mehrab |