| CatalogCode: | NB300-258 |
| ProductName: | Interferon Receptor Type 1, Subunit 1 (IFNAR1) Antibody |
| Product Description: | Rabbit Polyclonal anti-Interferon Receptor Type 1, Subunit 1 (IFNAR1) [Ser535/Ser539] |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic phosphopeptide corresponding to amino acid residues surrounding the human phospho-Ser 535, 539 type 1 interferon recoptor subunit 1 (IFNAR1). The antigen sequence used is virtually identical to the bovine, mouse, and rat forms of IFNAR1. |
| Specificity: | Specific for IFNAR1 phosphorylated at Ser535/539. |
| CrossReactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | Antibody dilutions and tissue load should be based on tissue type and expected phosphorylation state expected expression level. Initial recommended range of dilutions: 1:1000. Note: the molecular weight of the IFNNAR1 varies with cell line (different levels of glycosylation) in 293 and HeLa Cells; the mature form is ~110 - 130 kDa. |
| Localization: | Type I membrane protein. |
| Background: | Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon Receptor(IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-IFN alpha REC antibody; Anti-IFN alpha receptor antibody; Anti-IFN alpha/beta Receptor alpha antibody; Anti-IFNAR antibody; Anti-IFNAR1 antibody |
| ProteinTarget: | Interferon Receptor Type 1, Subunit 1 (IFNAR1), phosphorylated Ser 535, 539 Antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Biron, C.A. "Interferons alpha and beta as immune regulators-a new look," Immunity 14 (2001) 661-664. 2. Kirkwood, J. "Cancer immunotherapy: the interferon- experience," Semin. Oncol. 29 (2002) 18-26. 3. Stark, G.R., Kerr, I.M., Williams, B.R., Silverman, R.H. and Schreiber, R.D. "How cells respond to interferons." Annu. Rev. Biochem. 67 (1998) 227-264. 4. Suresh Kumar, K.G., Tang, W., Ravindranath, A.K., Clark, W.A., Croze, E. and Fuchs, S.Y. "SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the nterferonreceptor," The EMBO Journal, 22 (2003) 5480-5490. 5. Uze, G., Lutfalla, G. and Gresser, I. "Genetic transfer of a functional human interferon receptor into mouse cells: cloning and expression of its cDNA," Cell 60 (1990) 225-234. |
| Phosphorylated: | Ser535/Ser539 |
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