| CatalogCode: | NB300-203SS |
| ProductName: | HIP1 Antibody |
| Product Description: | Mouse Monoclonal anti-HIP1 (4B10) |
| Clone: | 4B10 |
| Clonality: | Monoclonal |
| Immunogen: | Human 3'-HIP1 (~65 kDa) |
| Specificity: | NB 300-203 is specific for human HIP1. |
| CrossReactivity: | NB 300-203 recognizes human HIP1 proteins. It does not appear to work in rat. Other species have not been tested. |
| Packaging: | 0.025 ml Mouse ascites. |
| Uses: | By Western blot, this antibody recognizes a band at ~115 kDa, representing HIP1 protein. The investigator should determine the optimal working dilution for a specific application. |
| Localization: | Localization: Cytoplasmic |
| Background: | Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers. |
| ProductRef: | 1. Hyun, Teresa S., et al., HIP1 and HIP1r Stabilize Receptor Tyrosine Kinases and Bind 3-Phosphoinositides via Epsin N-terminal Homology Domains. Biological Chemistry. 249(14):14292-14306. 2. Rao, Dinesh S., et al., Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. Clinical Investigation. 110(3):351-360 3. 1. Rao, Dinesh S., et al., Huntingtin Interacting Protein 1 Is a Clathrin Protein Required for Differentiation of late Spermatogenic Progenitors. Molecular and Cell Biology. 21(22):7796-7806 |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| ListPrice: | 100 |
| NovusRef: | 1. Rao, et al J. Clin. Invest. 110:351-360 (2002) 2. Mills, I.G., et al. Huntington interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. J. Cell Biol. 170(2): 191-200, 2005. (Western blot, bacteria) |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Rt(-) |
| ALTnames: | anti-HIP I antibody; anti-Huntingtin interacting protein 1 antibody |
| PackageSize: | 0.025 ml |
| GeneralRef: | 1. Rao, et al Mol. Cell. Bio. 21:7796-7806 (2001) 2. Saint-Dic, et al JBC. 276:21192-21198 (2001) 3. Rao, et al Can. Cell. 3:471-482 (2003) |