| CatalogCode: | NB300-203 |
| ProductName: | HIP1 Antibody |
| Product Description: | Mouse Monoclonal anti-HIP1 (4B10) |
| Clone: | 4B10 |
| Clonality: | Monoclonal |
| Immunogen: | Human 3'-HIP1 (~65 kDa) |
| CrossReactivity: | Human. Does not react with rat protein. Other species have not been tested. |
| Packaging: | 0.1 ml of mouse ascites (58 mg/ml) in PBS and 0.1% Sodium Azide. |
| Uses: | This antibody is useful for Western blot, where a band at approximately 115 kDa is seen. |
| Localization: | Cytoplasm |
| Background: | Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. In addition to playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers. |
| ProductRef: | 1. Hyun, Teresa S., et al., HIP1 and HIP1r Stabilize Receptor Tyrosine Kinases and Bind 3-Phosphoinositides via Epsin N-terminal Homology Domains. Biological Chemistry. 249(14):14292-14306. 2. Rao, Dinesh S., et al., Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. Clinical Investigation. 110(3):351-360 3. 1. Rao, Dinesh S., et al., Huntingtin Interacting Protein 1 Is a Clathrin Protein Required for Differentiation of late Spermatogenic Progenitors. Molecular and Cell Biology. 21(22):7796-7806 |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| ListPrice: | 285 |
| NovusRef: | 1. Rao, et al. J. Clin. Invest. 110: 351-360 (2002). 2. Mills, I.G., et al. Huntington interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. J. Cell Biol. 170(2): 191-200 (2005). (Western blot, bacteria) |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Rt(-) |
| ALTnames: | anti-HIP I antibody, anti-Huntingtin interacting protein 1 antibody |
| ProteinTarget: | HIP1 [4B10] antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Rao, et al Mol. Cell. Bio. 21:7796-7806 (2001) 2. Saint-Dic, et al JBC. 276:21192-21198 (2001) 3. Rao, et al Can. Cell. 3:471-482 (2003) |
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