| Catalog Code: | NB300-193 |
| Product Type: | Primary Antibody |
| Product Name: | GABA A receptor alpha 4 subunit Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 140675 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-GABA A receptor alpha 4 subunit |
| Cross Reactivity: | This antibody reacts with rat. Other species have not been tested. |
| Species Summary: | Rt |
| Background: | GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA |
| Alternate Names: | GABA(A) receptor subunit alpha 4 antibody, GABR A4 antibody, GABRA 4 antibody, GABRA4 antibody, Gamma aminobutyric acid (GABA) A receptor alpha 4 antibody, Gamma aminobutyric acid A receptor alpha 4 antibody, Gamma aminobutyric acid receptor alpha 4 subun |
| Immunogen: | Fusion protein of MBP with the amino acid sequence representing the cytosolic loop of the rat GABA-A receptor alpha 4 subunit. |
| Localization: | Integral membrane protein. |
| Specificity: | NB 300- 193 reacts with the C-terminus of the 64 kDa alpha 4 subunit of rat brain GABA-A. There is no known reactivity with other GABA subunits. There is no homology with other GABA subunits. |
| Purity: | Affinity purified |
| Buffer: | 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Uses: | NB 300-193 may be used for immunoprecipitation, and western analysis where a band is seen around 64 kDa. |
| Application Summary: | IP, WB |
| General References: | 1. Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (2003) A kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor beta-su |
| Novus References: | Pignataro, L., et al. Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1. J. Neurosci., Nov 2007; 27: 12957-12966 |