| Catalog Code: | NB300-191 |
| Product Type: | Primary Antibody |
| Product Name: | GABA A receptor alpha 1 subunit Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 29705 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-GABA A receptor alpha 1 subunit |
| Cross Reactivity: | This antibody reacts with rat and bovine. Other species have not been tested. |
| Species Summary: | Bv, Rt |
| Background: | GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA |
| Alternate Names: | anti-EJM antibody, anti-Gaba receptor alpha 1 polypeptide antibody, anti-GABA(A) receptor antibody, anti-GABRA 1 antibody, anti-GABRA1 antibody, anti-Gamma aminobutyric acid (GABA) A receptor alpha 1 antibody |
| Immunogen: | Synthetic peptide from the N-terminus of the rat GABA-A receptor alpha 1 subunit, coupled to KLH. |
| Localization: | Membrane; multi pass membrane protein. |
| Specificity: | NB 300- 191 reacts with the 51 kDa alpha 1 subunit of rat brain GABA-A. There is no known reactivity with other GABA subunits. There is no homology with other GABA subunits. |
| Purity: | Affinity purified |
| Buffer: | 10mM HEPES 9Ph7.5), 150nM NaCl, 100ug/ml BSA and 50% glycerol |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Concentration: | 0.15 mg/ml |
| Uses: | NB 300-191 may be used for Western analysis and immunoprecipitation. In Immunoprecipitation 15ug will precipitate 76% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains.The investigator should determine the optimal dilution for a specif |
| Application Summary: | IP, WB |
| General References: | 1. Zezula, J., et al, Separation of alpha 1, alpha 2, and alpha 3 subunits of the GABA-A-benzodiazepine receptor complex by immunoaffinity chromatography. Brain Res., 563: 325-8, 1991. |
| Novus References: | Herden, C., et al. Differential Effects of Methylmercury on GABAA Receptor Currents in Rat Cerebellar Granule and Cerebral Cortical Neurons in Culture. J. Pharmacol. Exp. Ther. published 31 October 2007, 10.1124/jpet.107.123976. |