| CatalogCode: | NB300-143SS |
| ProductName: | Growth Associated Protein-43 Antibody |
| Product Description: | Rabbit Polyclonal anti-Growth Associated Protein-43 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to amino acids 216-226 of rat/mouse GAP-43. (C)-KEDPEADQEHA coupled to maleimide-activated KLH |
| Specificity: | This antibody is specific for GAP-43. |
| CrossReactivity: | Human, chicken, rat, and mouse GAP-43.
Does not react with Xenopus. Other species have not been tested. |
| Packaging: | 0.025 ml Affinity purified Rabbit antisera. |
| Uses: | NB 300-143 can be used for western analysis where it recognizes a band at 43 kDa representing GAP-43. Immunohistochemistry on chicken has not been determined. |
| Localization: | Neuronal Marker Growth Cone |
| Control: | Embryonic nervous tissue, brain, injured nerve |
| Background: | GAP-43 is expressed by developing and regenerating neurons, and to a lesser extent, reactive glial cells. It is used widely to specifically label injured neurons and to score neuronal regeneration. |
| ProductRef: | 1. Teo, J., et al. PNAS 102(34): 12171-12176, 2005. 2. Oinuma, I., Katoh, H., and Negishi, M. (2007) R-Ras Controls Axon Specification Upstream of Glycogen Synthase Kinase-3beta through Integrin-linked Kinase, 282, 303-318. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | n/a |
| Host_Name: | Rabbit |
| Buffer: | PBS |
| ListPrice: | 100 |
| NovusRef: | 1. Berwanger, B., et al. Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma. Cancer Cell. 2:377-386, 2002. 2. Teo, J-L. Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. PNAS. 102:12171-12176, 2005. 3. Teo, J., et al. PNAS 102(34): 12171-12176, 2005. 4. Osterfield M, Egelund R, Young LM, Flanagan JG. Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development. March 15, 2008;135(6):1189-99. |
| AppSummary: | IHC, IF, WB, ICC |
| SpeciesSummary: | Ch, Hu, Mu, Rt, Xp(-) |
| ALTnames: | anti-Growth Associated Protein 43 antibody; anti-Nerve Growth Related Peptide antibody; anti-Neuromodulin antibody; anti-GAP43 antibodyl; anti-GAP-43 antibody |
| PackageSize: | 0.025 ml |
| GeneralRef: | 1. Ferguson, T.A., Muir, D. MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve. Mol Cell Neurosci. 16: 157-167, 2000. 2. Krekoski, C., et al. J. Neurosci. 21: 6206-6213, 2001. 3. Krekoski, C., et al. J. Neurosci. 22: 10408-3, 10415, 2002. 4. Zuo, J., et al. Exp. Neurol. 176: 221-228, 2002. |
| NotesMain: | GAP-43 is an abbreviation for Growth-Associated Protein 43kD |
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