| CatalogCode: | NB300-132 |
| ProductName: | Neurofilament light chain Antibody |
| Product Description: | Mouse Monoclonal anti-Neurofilament light chain (DA2) |
| Clone: | DA2 |
| Clonality: | Monoclonal |
| Immunogen: | NF-L purified from pig spinal cord |
| Epitope: | The epitope for this antibody is not in the N-terminus; however exactly where it is located is not known. It is thought to be somewhere within the central alpha helical "rod" region of the molecule. |
| Specificity: | Specifically recognizes the light neurofilament subunit or NF-L (~68 kDa). |
| CrossReactivity: | Human and other mammals. Also recognizes avian NF-L. |
| Packaging: | 0.05 ml Mouse ascites. |
| Uses: | The predicted molecular weight is 68 kDa. |
| Localization: | Cytoplasmic |
| Background: | Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-L antibody can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Lou Gehrig's disease or Alzheimer's disease. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| Buffer: | Ascitic fluid |
| ListPrice: | 285 |
| AppSummary: | IHC, IF, WB |
| SpeciesSummary: | Hu, Ma, Av |
| ALTnames: | anti-68 kDa neurofilament protein antibody; anti-CMT1F antibody; anti-CMT2E antibody; anti-NEFL antibody; anti-Neurofilament light polypeptide 68kDa antibody; anti-Neurofilament protein light chain antibody; anti-Neurofilament protein light polypeptide antibody; anti-Neurofilament triplet L protein antibody; anti-NF68 antibody; anti-NFL antibody |
| ProteinTarget: | Neurofilament light chain (NF-L ) |
| PackageSize: | 0.05 ml |
| GeneralRef: | 1. Edson, K. J. et al. J. Neurosci. Res. 30:105-115 (1991). 2. Shaw, G., et al. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. The FASEB Journal express article 10.1096/fj.01-0995fje. Published online April 10, 2002. |