| Catalog Code: | NB300-113 |
| Product Type: | Primary Antibody |
| Product Name: | Glycine Receptor Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 2556 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-Glycine Receptor |
| Cross Reactivity: | NB 300-113 reacts with rat and human. Other species have not been tested. |
| Species Summary: | Hu, Rt |
| Background: | Glycine is an important inhibitory neurotransmitter in the mammalian central nervous system, especially in the brainstem and spinal cord. It acts by binding to anion-conducting glycine receptors that belong to a superfamily of ligand-gated ion channels. |
| Immunogen: | NB 300-113 was raised against a KLH-conjugated synthetic peptide from the amino terminus of the human a1 glycine receptor subunit. [ARSATKPMSPSDFLDKLMGC] |
| Specificity: | NB 300-113 is specific to the ~48 kDa a1 and a2 subunits of the receptor in western blots of rat spinal cord and in cell extracts containing the recombinant human glycine receptors. Immunolabeling was blocked by preabsorption of the antibody with the imm |
| Purity: | Affinity purified |
| Buffer: | Lyophilized from 5 mM ammonium bicarbonate. The antibody should be reconstituted in 50 µl PBS |
| Packaging: | 0.2 mg Affinity purified Rabbit antisera. |
| Package Size: | 0.2 mg |
| Uses: | NB 300-113 can be used in Western blot and immunohistochemistry procedures |
| Application Summary: | WB, IHC-F |
| General References: | 1. Rajendra, S., et al. The glycine receptor. Pharmacol. Ther. 73: 121-146, 1997.2. Raymond, L.A., et al. Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase. Nature. 361: 637-641, 1993. |