| CatalogCode: | NB300-1019 |
| ProductName: | CD79a Antibody |
| Product Description: | Rabbit Polyclonal anti-CD79a |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human and Mouse). |
| CrossReactivity: | Cross-reacts with Human and Mouse. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody can be used for ELISA, IHC-P and Western Blot. In Western Blot, predicted molecular weight: 25 kDa. Sections require boiling in 10 mM citrate buffer, pH 6.0 for 10 min, followed by cooling at RT for 20 min. |
| Localization: | Cell Membrane |
| Background: | The CD79 molecule, comprising two polypeptide chains, mb-1 (CD79a) and B29 (CD79b), is physically associated in the B-cell membrane with immunoglobulins to constitute the B cell antigen receptor (BCR). The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling. Almost all acute lymphoblastic leukemias of precursor B cell type are positive when tested with CD79a antibodies. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS. pH 7.4 |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB, IHC-P |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-B cell antigen receptor complex associated protein alpha chain precursor antibody, anti-B Lymphocyte Specific MB1 Protein antibody, anti-CD79A antigen immunoglobulin associated alpha antibody, anti-Ig alpha antibody, anti-IGA antibody, anti-Immunoglobulin Associated Alpha antibody, anti-Ly54 antibody, anti-MB1 membrane glycoprotein antibody, anti- antibody, anti- antibody |
| ProteinTarget: | CD79a |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Chu PG & Arber DA CD79: a review. Appl Immunohistochem Mol Morphol 9:97-106 (2001). Payelle-Brogard B et al. Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. Blood 94:3516-22 (1999). Mason DY et al. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples. Blood 86:1453-9 (1995). |
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