| Catalog Code: | NB200-615 |
| Product Type: | Primary Antibody |
| Product Name: | Bad Antibody |
| List Price: | 325 |
| Clonality: | Monoclonal |
| Gene ID: | 572 |
| Host: | Rabbit |
| Clone: | Y208 |
| Isotype: | IgG |
| Product Description: | Rabbit Monoclonal anti-Bad (Y208) |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Species Summary: | Hu, Mu, Rt |
| Background: | Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, act |
| Alternate Names: | anti-Bcl-2 binding component 6 antibody, anti-BBC 2 antibody, anti-BBC2 antibody, anti-BBC6 antibody, anti-Bcl 2 Antagonist of Cell Death antibody, anti-Bcl 2 Binding Component 6 antibody, anti-BCL X / BCL 2 Binding Protein antibody, anti-BCL X Binding Pr |
| Immunogen: | A synthetic peptide corresponding to residues in the N-term of human Bad. |
| Specificity: | The antibody does not cross-react with other Bcl-2 members. |
| Purity: | Protein G purified |
| Buffer: | Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Packaging: | 100 microliters |
| Package Size: | 0.1ml |
| Uses: | WB: Use at a dilution of 1/2000-1/5000. IHC: Use at a dilution of 1/100-1/250. ICC: Use at a dilution of 1/250-1/500. FACS: Use at a dilution of 1/50. IP: Use at a dilution of 1/100. Not tested in other applications. Optimal dilutions/concentrations shoul |
| Application Summary: | WB, IHC, ICC, FACS, IP |
| General References: | 1. Greider, C.W., and Blackburn, E.H. (1985). Cell 43, 405-413 2. Feng J, Funk WD, Wang SS, et al. Science 1995; 269:1236-41 3. Greider, C.W. (1996). Telomere length regulation. Annu. Rev. Biochem. 65, 337-3654. Shay JW, Cacchetti SA, Eur J Cancer. 1997:3 |
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