| CatalogCode: | NB200-586 |
| ProductName: | PKC alpha Antibody |
| Product Description: | Mouse Monoclonal anti-PKC alpha (MC5) |
| Clone: | MC5 |
| Clonality: | Monoclonal |
| Immunogen: | Purified bovine brain protein kinase C |
| CrossReactivity: | Cross-reacts with Human, Rat, Mouse, Cow, Dog, Fish, Guinea Pig, Monkey, Pig, Rabbit and Sheep. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | Proteolysis Blocking: Use at a dilution of 2mg/ml. Optimal dilutions should be determined by the end user. |
| Control: | Mouse brain tissue extract and rat brain tissue extract |
| Background: | Protein Kinase C (PKC) is a large superfamily of serine/threonine kinases that mediate essential cellular signals required for activation, proliferation, differentiation and survival. There are at least ten PKC isotypes that are closely related in structure but that have distinct patterns of tissue distribution and function. The PKC isotypes can be subdivided into three classes based on primary structure and biochemical properties. These are: classical or conventional PKC isotypes (cPKC), novel PKC isotypes (nPKC) and atypical PKC isotypes (aPKC). All PKC isotypes share a characteristic equence motif C1 in addition to a serine/threonine-protein kinase domain. The cPKC isotypes include PKC |
| ProductRef: | 1. Zhang, C.-L., Zou, Y., Yu, R. T., Gage, F. H., and Evans, R. M. (2006) Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1, 20, 1308-1320. 2. Zhang, C.-L., Zou, Y., Yu, R. T., Gage, F. H., and Evans, R. M. (2006) Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1, 20, 1308-1320. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Mouse |
| Buffer: | PBS, 0.1 mM PMSF, 50% glycerol |
| ListPrice: | 295 |
| AppSummary: | ELISA, IP, WB |
| SpeciesSummary: | Bv, Ca, Hu, Mu, Po, Mk, Rt, Rb, Gp, Fi, Sh |
| ALTnames: | anti-Protein Kinase C antibody |
| ProteinTarget: | PKC (Protein Kinase C) |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Young, S. et al (1988) Eur. J. Biochem. 173: 247-252. 2. Ng T et al. 1999. EMBO J. 18:3909-3923. 3. Robinson-White, A and Stratakis, C.A. (2002) Ann. N. Y. Acad. Sci. 968: 256-270. 4. Shirai, Y. and Saito, N. (2002) J. Biochem. 132: 663-668. 5. Saijo, K., Mecklenbrauker, I., Schmedt, C. and Tarakhovsky, A. (2003) Ann. N. Y. Acad. Sci. 987: 125-134. 6. da Rocha, A.B., Mans, D. R., Regner, A., Schwartsmann, G. (2002) Oncologist 7: 17-33. 7. Frank, R.N. (2002) Am. J. Ophthalmol. 133: 693-698. |
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