| CatalogCode: | NB200-413 |
| ProductName: | Troponin T, cardiac Antibody |
| Product Description: | Mouse Monoclonal anti-Troponin T, cardiac (7A9) |
| Clone: | 7A9 |
| Clonality: | Monoclonal |
| Immunogen: | Full length protein (Human). |
| Epitope: | Peptide 180-287. |
| Specificity: | This antibody is specific for cadiac troponin. Does not cross-react with skeletal muscle troponin T, cTnI and TnC. |
| CrossReactivity: | Cross-reacts with human, cow, dog, goat and rabbit. Does not cross-react with mouse, rat, cat, fish or pig. Not yet tested in other species. |
| Packaging: | 0.2 mg of protein A purified ascites. |
| Uses: | AP: Use at an assay dependent dilution. ELISA: Use at an assay dependent dilution. IA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 35.4 kDa. Not tested in other applications. *Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Located on the thin filament of striated muscles. |
| Background: | Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations within the protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the gene undergo alternative splicing that results in many tissue-specific isoforms. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS. pH 7.4 containing 0.1% Sodium Azide |
| ListPrice: | 245 |
| AppSummary: | IP, ELISA, WB |
| SpeciesSummary: | Hu, Bv, Ca, Gt, Rb, Mu(-), Rt(-), Fe(-), Fi(-), Po(-) |
| ALTnames: | anti-CMD1D antibody, anti-CMH2 antibody, anti-cTnT antibody, anti-MGC3889 antibody, anti-TNNT2 antibody, anti-TnTC antibody, anti-Troponin T2 antibody |
| ProteinTarget: | Troponin T, cardiac antibody [7A9] |
| PackageSize: | 0.2 mg |
| GeneralRef: | 1. Sarko J & Pollack CV Cardiac troponins. J Emerg Med 23:57-65 (2002). 2. Gomes AV et al. The role of troponins in muscle contraction. IUBMB Life 54:323-33 (2002). 3. Hamm CW Acute coronary syndromes. The diagnostic role of troponins. Thromb Res 103 Suppl 1:S63-9 (2001). 4. Labugger R et al. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 102:1221-6 (2000). 5. Wu AH et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin Chem 44:1198-208 (1998). 6. Katrukha AG et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 43:1379-85 (1997). |
| NotesMain: | Concentration varies from lot to lot and can be provided on request.
Troponin-T mouse monoclonal, clone 1C11 (NB 200-412) is available, as well. Also available are clones 9G6, 7F4, 1F2, 7G7, 3D6, 2F3, 6G9, 1A11, 2G3,1F11, and 5C12. |