| CatalogCode: | NB200-309 |
| ProductName: | SMRT Antibody |
| Product Description: | Mouse Monoclonal anti-SMRT (H7) |
| Clone: | H7 |
| Clonality: | Monoclonal |
| Immunogen: | A synthetic peptide from the human SMRT protein corresponding to amino acids 994-1005 (ASASDPHREKTQ) coupled to KLH. |
| Specificity: | This antibody is specific for SMRT. |
| CrossReactivity: | NB 200-309 reacts with human SMRT. |
| Packaging: | 0.1 ml Mouse ascites. |
| Uses: | Immunoblotting and immunoprecipitation. Clone H7 recognizes the Silencing Mediator for Retinoid and Thyroid receptors (SMRT) gene product, a 168 kDa nuclear protein. |
| Control: | HBL100 |
| Background: | Nuclear hormone receptors are transcription factors regulated by ligand binding. In the absence of ligand there is a physical interaction between the nuclear receptors that do not interact with Hsp90 and a family of corepressors which includes SMRT. SMRT helps target histone deacetylases and other components of a multiprotein repressor complex to the specific target promoter to silence gene transcription. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1/k |
| Host_Name: | Mouse |
| Buffer: | No buffer. |
| ListPrice: | 285 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-NCoR 2 antibody, anti-nuclear receptor co-repressor 2 antibody, anti-Silencing Mediator for Retanoid and Thyroid Hormone Receptors antibody, anti-SMRT antibody, anti-SMRTE antibody |
| ProteinTarget: | SMRT |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1.Chen, D.J. and Evans, R.M. (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457 |
| NotesMain: | Hybridoma: Fusion between BALB/c splenocytes and mouse myeloma (Fox-NY cells). |
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