| CatalogCode: | | NB200-302 |
| ProductName: | | Estrogen Receptor Beta Antibody |
| Product Description: | | Rabbit Polyclonal anti-Estrogen Receptor Beta |
| Clonality: | | Polyclonal |
| Immunogen: | | Recombinant 6-His fusion protein encoding amino acids 1-153 of human ER-ß expressed in E. coli. |
| Specificity: | | This antibody is specific for Estrogen receptor-Beta. |
| CrossReactivity: | | NB 200-302 reacts with human ER-Beta |
| Packaging: | | 0.05 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | | By Western blot, this antibody recognizes ER-b. |
| Background: | | The human ER-ß is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-ß is very similar to ER-a with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domains have diverged significantly. Similar in function to ER-a, ER-ß binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's). |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Host_Name: | | Rabbit |
| Buffer: | | PBS, 1 mg/ml BSA and 0.05% sodium azide |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-ER beta antibody |
| ProteinTarget: | | Estrogen Receptor (beta) |
| PackageSize: | | 0.05 ml |
| GeneralRef: | | 1.Mosselman, S., Polman, J., and Dijkema, R. ERb: Identification and characterization of a novel human estrogen receptor. FEBS Letter. 392: 49-53, 1996. 2.Dotlaw, H., Leygue, E., Watson, P.H., and L.C. Murphy. Expression of estrogen receptor-beta in human breast tumors. J. Clin. Endo. Metab. 82: 2371-2374, 1996. 3.Kuiper, G.G.J.M., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., and J.A. Gustaffson. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptor d and b. Endocrinology 138: 863-870, 1997. |
| more information: | | company product webpage |
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