| CatalogCode: | NB200-170SS |
| ProductName: | PRG3 Antibody |
| Product Description: | Rabbit Polyclonal anti-PRG3 **Sample Size** |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to residues 170-185 [VTLIHSQVALADKELL] of the 41 kDa human PRG3 protein. This sequence is 87% identical in mouse. |
| Specificity: | This antibody is specific for human PRG3. |
| CrossReactivity: | Human. Other species have not been tested. |
| Packaging: | 0.025 ml Rabbit antisera. |
| Uses: | This antibody has been tested in Western blot. No other applications have been tested. Recommended dilution below.Western Blot - 1:500However, the investigator should determine the optimal dilution. |
| Background: | The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host_Name: | Rabbit |
| ListPrice: | 100 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Cys51Stop antibody, anti-HGNC11998 antibody, anti-p53 tumor suppressor antibody, anti-TRP53 antibody, anti-tumor protein p53 antibody |
| PackageSize: | 0.025 ml |
| GeneralRef: | 1. Ohiro Y. et al. FEBS Lett. 2002 Jul 31;524(1-3):163-71. |
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