| Catalog Code: | NB200-103 |
| Product Type: | Primary Antibody |
| Product Name: | p53 Antibody |
| List Price: | 295 |
| Clonality: | Monoclonal |
| Gene ID: | 7157 |
| Host: | Mouse |
| Clone: | PAb 240 |
| Isotype: | IgG1 kappa |
| Product Description: | Mouse Monoclonal anti-p53 (PAb 240) |
| Cross Reactivity: | Cross-reacts with Human, Mouse, Rat and most other Mammals.Does not cross-react with Xenopus laevis. Not yet tested in other species. |
| Species Summary: | Hu, Mu, Rt, Xp(-) |
| Background: | The tumor suppressor protein p53 plays an important role in cancer development. The p53 protein is a transcription factor that acts as a checkpoint in the cell cycle, either preventing or initiating programmed cell death. Since cancer occurs as the malfun |
| Alternate Names: | anti-Cys 51 Stop antibody, anti-HGNC11998 antibody, anti-p53 Cellular Tumor Antigen antibody, anti-p53 Tumor Suppressor antibody, Phosphoproteinp53 antibody, anti-TP53 antibody, anti-Transformation related protein 53 antibody, anti-TRP53 antibody, anti-Tu |
| Immunogen: | Gel-purified p53-beta-galactosidase fusion protein containing murine p53 from aa 14-389 (derived from pSV53C cDNA clone). |
| Epitope: | The epitope has been mapped between amino acids 213 and 217 on human p53. |
| Localization: | Nuclear |
| Specificity: | This monoclonal antibody recognizes both mutant forms and wild-type human p53 under denaturing conditions. |
| Purity: | Affinity purified |
| Buffer: | Phosphate buffered saline |
| Packaging: | 0.1 mg Affinity purified Mouse ascites. |
| Package Size: | 0.1 mg |
| Uses: | ELISA, FACS, IHC-P Antigen retrieval is not essential but may optimise staining. IHC-Fr, IP, by IP, this antibody reacts with only mutant p53 protein under non-denaturing conditions. Westerbn blot. |
| Application Summary: | FACS, ELISA, IHC-P, IP, WB, IHC-P, IHC-F |
| General References: | Said JW et al. Immunohistochemical analysis of p53 expression in malignant lymphomas. Am J Pathol 141:1343-8 (1992). PUBMED:1466398 Bartek J et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. On |