| CatalogCode: | NB120-9474 |
| ProductName: | Androgen Receptor Antibody |
| Product Description: | Mouse Monoclonal anti-Androgen Receptor (AR 441) |
| Clone: | AR 441 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide: STEDTAEYSPFKGGYTK, corresponding to amino acids 299-315 of Human Androgen Receptor. |
| Specificity: | This antibody is specific to a protein of 110 kD, identified as androgen receptor. This antibody reacts with full length androgen receptor and also with the newly described A form of the receptor. This antibody does not cross react with estrogen, progesterone or glucocorticoid receptors. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.25 ml Tissue culture supernatant Mouse ascites. |
| Uses: | IHC: Suggested incubation period of 30 minutes at RT. For formalin fixed paraffin embedded sections, perform heat mediated antigen retrieval using 10mM citrate buffer pH6.0 before commencing with the IHC staining protocol. |
| Localization: | Nuclear |
| Control: | Prostrate Carcinoma. |
| Background: | Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain. The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | n/a |
| ListPrice: | 285 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-AIS antibody, anti-Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) antibody, anti-AR antibody, anti-DHTR antibody, anti-Dihydro Testosterone Receptor antibody, anti-Dihydrotestosterone receptor antibody, anti-HUMARA antibody, anti-KD antibody, anti-NR3C4 antibody, anti-SBMA antibody, anti-SMAX1 antibody, anti-TFM antibody |
| ProteinTarget: | Androgen Receptor |
| PackageSize: | 0.25 ml |