| CatalogCode: | NB120-9021 |
| ProductName: | Cytokeratin 7 Antibody |
| Product Description: | Mouse Monoclonal anti-Cytokeratin 7 (RCK105) |
| Clone: | RCK105 |
| Clonality: | Monoclonal |
| Immunogen: | Cytokeratins from the human bladder carcinoma cell line T24. |
| Specificity: | This antibody reacts exclusively with cytokeratin 7 which is present in a subgroup of glandular epithelia and their tumors, as well as transitional epithelium and transitional carcinoma. |
| CrossReactivity: | Cross-reacts with Cat, Dog, Hamster, Human, Mouse, Pig and Rat. Not yet tested in other species. |
| Packaging: | 0.1 mg Tissue culture supernatant Mouse ascites. |
| Localization: | Cytoplasmic |
| Background: | Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 ? 7.8. The individual human cytokeratins are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Constituents: PBS. pH 7.4 |
| ListPrice: | 325 |
| AppSummary: | FACS, IHC, WB, ICC |
| SpeciesSummary: | Ca, Ha, Hu, Mu, Po, Rt, Fe |
| ALTnames: | Anti-CK 7 antibody; Anti-ck7 antibody; Anti-Cytokeratin7 antibody; Anti-K2C7 antibody; Anti-K7 antibody; Anti-Keratin 55k type ii cytoskeletal antibody; Anti-Keratin 7 antibody; Anti-Keratin simple epithelial type 1 k7 antibody; Anti-Keratin type ii cytoskletal 7 antibody; Anti-Keratin7 antibody; Anti-KRT 7 antibody; Anti-KRT7 antibody; Anti-MGC129731 antibody; Anti-mgc3625 antibody; Anti-Sarcolectin antibody; Anti-SCL antibody; Anti-Type ii mesothelial keratin k7 antibody |
| ProteinTarget: | Cytokeratin 7 |
| PackageSize: | 0.1 mg |
| GeneralRef: | This product has been used in:Ramaekers F et al. Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas. Am J Pathol 136:641-55 (1990). Ramaekers F et al. Tissue distribution of keratin 7 as monitored by a monoclonal antibody. Exp Cell Res 170:235-49 (1987). General / background references:Bauwens LJ et al. Expression of intermediate filament proteins in the adult human vestibular labyrinth. Ann Otol Rhinol Laryngol 101:479-86 (1992). Smedts F et al. Keratin expression in cervical cancer. Am J Pathol 141:497-511 (1992). Ivanyi D et al. Patterns of expression of feline cytokeratins in healthy epithelia and mammary carcinoma cells. Am J Vet Res 53:304-14 (1992). Smedts F et al. Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia. Am J Pathol 136:657-68 (1990). Schaafsma HE et al. Distribution of cytokeratin polypeptides in human transitional cell carcinomas, with special emphasis on changing expression patterns during tumor progression. Am J Pathol 136:329-43 (1990). |
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