| CatalogCode: | NB120-8822 |
| ProductName: | Factor VIII Related Antigen Antibody |
| Product Description: | Sheep Polyclonal anti-Factor VIII Related Antigen , conjugated to FITC |
| Clonality: | Polyclonal |
| Immunogen: | Human Von Willebrand Factor Antigen prepared from citrated human plasma. Greater than 95% purity by SDS-PAGE. |
| Specificity: | The unconjugated immunoglobulin gives no arcs when tested by immunoelectrophoresis against human serum. Identity has been confirmed by double diffusion (Ouchterlony) against von Willebrand Factor and an anti-von Willebrand Factor of known specificity. |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 1 ml Immunogen affinity purified Sheep IgG. |
| Uses: | For direct immunofluorescence on frozen sections: 1/50 ? 1/100 The optimal dilution should be determined by the individual laboratory. |
| Localization: | Secreted. Located in storage granules. |
| Background: | Von Willebrand Factor (VWF) was previously known as Factor VIII related antigenis. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Sheep |
| Buffer: | PBS, pH 7.2, sodium azide, 0.1% |
| ListPrice: | 285 |
| AppSummary: | IF |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Von Willebrand Factor antibody, anti-Coagulation factor VIII antibody, anti-F8VWF antibody, anti-von Willebrand antigen 2 antibody, anti-Von Willebrand antigen II antibody, anti-Von Willebrand disease antibody, anti-VWD antibody, anti-VWF antibody |
| ProteinTarget: | Factor VIII Related Antigen |
| PackageSize: | 1 ml |
| Conjugate: | FITC |
| NotesMain: | Slight precipitation can occur on storage which may be removed by centrifugation and should not affect performance characteristics. |