| CatalogCode: | NB120-871 |
| ProductName: | CD30 Antibody |
| Product Description: | Mouse Monoclonal anti-CD30 (Ber-H2) |
| Clone: | Ber-H2 |
| Clonality: | Monoclonal |
| Immunogen: | BALB/C mice were injected with L428 cell line cells. |
| Specificity: | This antibody reacts with mononuclear cells in Hodgkin lymphoma, Reed-Sternberg cells and most anaplastic large cell lymphomas. It stains large cells localized around the B cell in the lymphoid tissues. This antibody stains the cell surface and the golgi |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 6 ml Purified Mouse IgG. |
| Uses: | This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections. No further titration is required. We suggest an incubation period of 60 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. |
| Localization: | Type I membrane protein (long isoform); cytoplasmic (short isoform). |
| Background: | CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that coexpress CD45RO and the IL4 receptor. |
| Storage: | Store at 4C. Do not freeze. |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| Buffer: | PBS with sodium azide |
| ListPrice: | 285 |
| AppSummary: | IHC-Fr, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CD 30 antibody, anti-CD153 antibody, anti-CD30 antigen antibody, anti-CD30L receptor antibody, anti-Cytokine receptor CD30 antibody, anti-D1S166E antibody, anti-KI 1 antibody, anti-Ki 1 antigen antibody, anti-KI1 antibody, anti-Lymphocyte activation antigen CD30 antibody, anti-TNFRSF8 antibody, anti-Tumor Necrosis Factor Receptor Superfamily Member 8 antibody |
| ProteinTarget: | CD30 |
| PackageSize: | 6 ml |
| GeneralRef: | General / background references:Pallesen G The diagnostic significance of the CD30 (Ki-1) antigen. Histopathology 16:409-13 (1990). Schwarting R et al. BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed |
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