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| Catalog Code: | NB120-8405 |
| Product Name: | DcR 3 Antibody |
| Product Description: | Rabbit Polyclonal anti-DcR 3 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Peptide corresponding to amino acids 31 to 46 ofhuman DcR3 precursor (1,2). |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Rabbit antisera. |
| Uses: | This product is useful in western blot, where a band is seen around 33 kDa. |
| Localization: | Secreted |
| Background: | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1and DcR2, DcR3 is a soluble rather than a membraneassociated molecule. DcR3 binds to FasL and LIGHT andinhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and coloncarcinomas and in some normal tissues. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS with 0.02% sodium azide |
| Application Summary: | Western Blot 1:500 - 1:1,000 |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Decoy Receptor 3 antibody, anti-Decoy receptor for Fas ligand antibody, anti-TR6 antibody, anti-Tumor necrosis factor receptor superfamily member 6b decoy antibody |
| Package Size: | 0.05 mg |
| General References: | General / background references:Yu KY et al. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem 274:13733-6 (1999). Pitti RM et al. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 396:699-703 (1998). |
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