| CatalogCode: | | NB120-8345 |
| ProductName: | | Myoglobin Antibody |
| Product Description: | | Mouse Monoclonal anti-Myoglobin (7C3) |
| Clone: | | 7C3 |
| Clonality: | | Monoclonal |
| Immunogen: | | Human cardiac myoglobin |
| Specificity: | | Human cardiac myoglobin |
| CrossReactivity: | | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | | 0.2 mg protein A purified Mouse IgG. |
| Uses: | | ELISA: Use at an assay dependent dilution. IA: Use at an assay dependent dilution. Can be paired for ELISA with <ab8343>Mouse monoclonal [4E2] to myoglobin</ab>.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Cytoplasmic |
| Background: | | Myoglobin is a small heme containing protein (153 amino acid residues, molecular weight (w/o heme) 17053 Da and theoretical pI=7.29) responsible for the oxygen deposition in muscle tissues. Only one form of myoglobin is expressed in cardiac and skeletal muscles. Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades. Nowadays it still is very commonly used in clinical practice as an early marker of AMI. It appears in patient's blood 1 to 3 hours after onset of the symptoms, reaching peak level within 8 to 12 hours. Myoglobin is not so cardiac specific as cTnI or cTnT. Because of high myoglobin concentration in skeletal muscle tissue, even minor skeletal muscle injury results in the significant increase of myoglobin concentration in blood. Thus myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis. |
| Storage: | | Store at 4C. Do not freeze. |
| Purity: | | protein A purified |
| Isotype: | | IgG1 |
| Host_Name: | | Mouse |
| Buffer: | | PBS pH 7.4 |
| ListPrice: | | 285 |
| AppSummary: | | ELISA |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-MB antibody, anti-MGC13548 antibody, anti-PVALB antibody |
| ProteinTarget: | | Myoglobin |
| PackageSize: | | 0.2 mg |
| GeneralRef: | | <b>General / background references:</b>Penttila K <i>et al.</i> Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain. <i>Clin Biochem</i> <b>35</b>:647-53 (2002). <PUBMED:12499000>Srinivas VS <i>et al.</i> Myoglobin levels at 12 hours identify patients at low risk for 30-day mortality after thrombolysis in acute myocardial infarction: a Thrombolysis in Myocardial Infarction 10B substudy. <i>Am Heart J</i> <b>142</b>:29-36 (2001). <PUBMED:11431653>Van Nieuwenhoven FA <i>et al.</i> Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein. <i>Circulation</i> <b>92</b>:2848-54 (1995). <PUBMED:7586251>Kagen L <i>et al.</i> Serum myoglobin in myocardial infarction: the "staccato phenomenon." Is acute myocardial infarction in man an intermittent event? <i>Am J Med</i> <b>62</b>:86-92 (1977). <PUBMED:835594> |
| more information: | | company product webpage |