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| Catalog Code: | NB120-8296 |
| Product Name: | Troponin T Antibody |
| Product Description: | Mouse Monoclonal anti-Troponin T (9G6) |
| Clone: | 9G6 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Full length native protein (purified) (Human). |
| Epitope: | 1-60 aa |
| Specificity: | This antibody detects Troponin T in human cardiac muscle. No cross-reaction with skeletal troponin T, or TnC or cTnI. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.2 mg protein A purified Mouse IgG. |
| Uses: | AP: Use at an assay dependent concentration. ELISA: Use at an assay dependent dilution. EIA: Use at an assay dependent concentration. WB: Use at an assay dependent dilution. Can be paired for ELISA with <ab8295>Mouse monoclonal [1C11] to cardiac Troponin T</ab>. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic. Mostly over the I bands |
| Background: | Cardiac Troponin T, a 36kDa protein, is the tropomyosin binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations within the protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the gene undergo alternative splicing that results in many tissue specific isoforms. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS pH 7.4 |
| Application Summary: | immunoprecipitation, EIA, ELISA, Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-Cardiac muscle troponin T antibody, anti-CMD1D antibody, anti-CMH2 antibody, anti-cTnT antibody, anti-MGC3889 antibody, anti-TNNT 2 antibody, anti-TNNT2 antibody, anti-TnTC antibody, anti-Troponin T cardiac muscle antibody, anti-Troponin T type 2 (cardiac) antibody, anti-Troponin T2 antibody |
| Package Size: | 0.2 mg |
| Preservative: | 0.1% sodium azide |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone: 1C11-9G6 For Sandwich ELISA pair this antibody with: NB200-412 |
| General References: | General / background references:Sarko J & Pollack CV Cardiac troponins. J Emerg Med 23:57-65 (2002). Gomes AV et al. The role of troponins in muscle contraction. IUBMB Life 54:323-33 (2002). Hamm CW Acute coronary syndromes. The diagnostic role of troponins. Thromb Res 103 Suppl 1:S63-9 (2001). Labugger R et al. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 102:1221-6 (2000). Wu AH et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin Chem 44:1198-208 (1998). Katrukha AG et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 43:1379-85 (1997). |
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