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| Catalog Code: | NB120-8291 |
| Product Name: | Troponin I Phosphospecific Antibody |
| Product Description: | Mouse Monoclonal anti-Troponin I (5E6) [Arg22/Ser23] |
| Clone: | 5E6 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Phosphorylated form of cardiac troponin I (phosphorylated in the 22nd and 23rd position) |
| Specificity: | Phosphorylated form of cardiac troponin I |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.2 mg protein A purified Mouse IgG. |
| Uses: | ELISA: Use at an assay dependent dilution. EIA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 25 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host Name: | Mouse |
| Buffer: | PBS with pH 7.4 |
| Application Summary: | EIA, ELISA, Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-CMH7 antibody, anti-cTnI antibody, anti-Familial hypertrophic cardiomyopathy 7 antibody, anti-MGC116817 antibody, anti-TNN I3 antibody, anti-TNNC 1 antibody, anti-TNNC1 antibody, anti-TNNI3 antibody, anti-Troponin I cardiac muscle antibody, anti-Troponin I type 3 cardiac antibody, anti-TroponinI antibody |
| Package Size: | 0.2 mg |
| Preservative: | 0.1% sodium azide |
| Phosphorylated: | Arg22/Ser23 |
| General References: | General / background references:Sarko J & Pollack CV Cardiac troponins. J Emerg Med 23:57-65 (2002). Gomes AV et al. The role of troponins in muscle contraction. IUBMB Life 54:323-33 (2002). Hamm CW Acute coronary syndromes. The diagnostic role of troponins. Thromb Res 103 Suppl 1:S63-9 (2001). Labugger R et al. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 102:1221-6 (2000). Wu AH et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. Clin Chem 44:1198-208 (1998). Katrukha AG et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 43:1379-85 (1997). Cummins B et al. Cardiac-specific troponin-I radioimmunoassay in the diagnosis of acute myocardial infarction. Am Heart J 113:1333-44 (1987). |
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