| CatalogCode: | NB120-826 |
| ProductName: | Cathepsin D Antibody |
| Product Description: | Rabbit Polyclonal anti-Cathepsin D |
| Clonality: | Polyclonal |
| Immunogen: | Cathepsin D isolated from human liver |
| Specificity: | This antibody reacts with the zymogen as well as the activated form of cathepsin D. It stains fibroblasts and macrophages strongly but stains weakly with the myoepithelial cells of breast. It also stains sweat ducts and glands in the skin, islets cells and granules of pancreatic acini. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.25 ml IgG purified Rabbit antisera. |
| Uses: | IHC: This antibody may be diluted to a titer of 1:75-1:200 in an ABC method. Staining Protocol: We suggest an incubation period of 30-60 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions and antibody dilutions should be determined by the user. |
| Localization: | Cytoplasmic |
| Control: | Breast Carcinoma |
| Background: | Cathepsin D has been reported to be involved in malignant tumour progression and with prognosis of various human cancers. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS and BSA |
| ListPrice: | 295 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu |
| ProteinTarget: | Cathepsin D |
| PackageSize: | 0.25 ml |
| GeneralRef: | This product has been used in:Henry JA et al. Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study. Cancer 65:265-71 (1990). General / background references:Garcia M et al. Immunohistochemical distribution of the 52-kDa protein in mammary tumors: a marker associated with cell proliferation rather than with hormone responsiveness. J Steroid Biochem 27:439-45 (1987). |
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