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| Catalog Code: | NB120-8105 |
| Product Name: | p53R2 Antibody |
| Product Description: | Rabbit Polyclonal anti-p53R2 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 2.79 mg/ml |
| Immunogen: | Synthetic peptide: GDPERPEAAGLDQDER, corresponding to amino acids 2-17 of Human p53R2. |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Rabbit antisera. |
| Uses: | This antibody can be used for detection of p53R2 by Western blot a 39 kDa band can be detected. |
| Storage: | The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by ultraviolet and g-irradiation that cause DNA damage. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumour suppression. |
| Purity: | Store at 4C. Do not freeze. |
| Isotype: | IgG purified |
| Host Name: | IgG |
| Buffer: | Rabbit |
| Application Summary: | PBS |
| Species Summary: | Western Blot 0.5 to 1 ug/ml |
| Alternate Names: | Hu, Mu, Rt, |
| Package Size: | anti-DKFZp686M05248 antibody, anti-MGC102856 antibody, anti-MGC42116 antibody, anti-p53 inducible ribonucleotide reductase small subunit 2 homolog antibody, anti-p53 inducible ribonucleotide reductase small subunit 2 like protein antibody, anti-p53 R2 antibody, anti-Ribonucleoside diphosphate reductase M2 subunit B antibody, anti-Ribonucleotide reductase M2 B (TP53 inducible) antibody, anti-Ribonucleotide reductase M2 B antibody, anti-Ribonucleotide reductase small subunit like 2 p53 inducible antibody, anti-RRM 2B antibody, anti-RRM2B antibody, anti-TP53 inducible ribonucleotide reductase M2 B antibody |
| Preservative: | 0.05 mg |
| Homology: | 0.02% sodium azide |
| Product References: | This product has been used in:Mansson E et al. Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance. Biochem Pharmacol 65:237-47 (2003). General / background references:Tanaka H et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 404:42-9 (2000). Oda E et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053-8 (2000). Oda K et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102:849-62 (2000). Luo J et al. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408:377-81 (2000). Lin Y et al. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat Genet 26:122-7 (2000). Lozano G & Elledge SJ p53 sends nucleotides to repair DNA. Nature 404:24-5 (2000). Nakano K et al. A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene 19:4283-9 (2000). Matsuoka S et al. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282:1893-7 (1998). |
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