| CatalogCode: | NB120-8104 |
| ProductName: | GPR 15 Antibody |
| Product Description: | Rabbit Polyclonal anti-GPR 15 |
| Clonality: | Polyclonal |
| Immunogen: | Peptide corresponding to amino acids 13 to 28of human GPR15 (1). The sequence differs from those ofAfrican green monkey and pig-tailed macaque BOB byone amino acid (2) |
| Specificity: | Rabbit anti-GPR15 polyclonal antibody was raised against a peptide corresponding to amino acids near the N-terminus of human GPR15 (1). The sequence differs from those of African green monkey and pig-tailed macaque BOB by only one amino acid (2). Anti-GPR15 reacts with GPR15 at the molecular weight of 50 kDa on western blot. Species reactivity includes human, mouse, and rat, while others are not tested. |
| CrossReactivity: | Cross-reacts with Human, Rat and Mouse.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit IgG. |
| Uses: | Western blot at 1:500 to 1:2000 dilution and an approximately 50 kDa band can be detected. |
| Control: | Jurkat whole cell lysate, A549 whole cell lysate. |
| Background: | Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3,CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively) were recently cloned. This novel G protein-coupled receptor serves as coreceptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1. The ligand for GPR15 has not been identified yet. |
| Storage: | Store at 2-8 °C for up to 1 year. Avoid repeated freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS (pH 7.4) |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | GPR 15 |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Deng HK et al. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296-300 (1997). Farzan M et al. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J Exp Med 186:405-11 (1997). Heiber M et al. A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3. Genomics 32:462-5 (1996). |
| NotesMain: | Stable for one year. |