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| Catalog Code: | NB120-8023 |
| Product Name: | Bonzo Antibody |
| Product Description: | Rabbit Polyclonal anti-Bonzo |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide, corresponding to amino acids 11-25 of Human Bonzo. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Rabbit antisera. |
| Uses: | Western blot at 1:500. |
| Background: | Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require co-receptors, in addition to CD4, to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV co-receptors. An orphan G protein coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV co-receptor (1-4). Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS with 0.02% sodium azide |
| Application Summary: | Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-C X C chemokine receptor type 6 antibody, anti-CD 186 antibody, anti-CD186 antibody, anti-CD186 antigen antibody, anti-CDw186 antibody, anti-Chemokine C-X-C Motif Receptor 6 antibody, anti-Chemokine CXC motif receptor 6 antibody, anti-Chemokine receptor 6 antibody, anti-CXC chemokine receptor type 6 antibody, anti-CXC R6 antibody, anti-CXCR 6 antibody, anti-CXCR6 antibody, anti-G protein coupled receptor antibody, anti-G protein coupled receptor bonzo antibody, anti-G protein coupled receptor STRL 33 antibody, anti-G protein coupled receptor STRL33 antibody, anti-G protein coupled receptor TYMSTR antibody, anti-STRL 33 antibody, anti-STRL33 antibody, anti-TYMSTR antibody |
| Package Size: | 0.05 mg |
| General References: | General / background references:Liao F et al. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med 185:2015-23 (1997). Deng HK et al. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296-300 (1997). Alkhatib G et al. A new SIV co-receptor, STRL33. Nature 388:238 (1997). Loetscher M et al. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol 7:652-60 (1997). |
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