| CatalogCode: | NB120-7967 |
| ProductName: | STAT4 Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT4 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Mouse) (C terminal). |
| Specificity: | Reacts with Stat4 of mouse, rat, and human origin |
| CrossReactivity: | Cross-reacts with Human, Rat and Mouse.Not yet tested in other species. |
| Packaging: | 1 ml IgG purified Rabbit IgG. |
| Uses: | Western blotting, immunoprecipitation, and immunohistochemistry. Western blotting starting dilution: 1:200. |
| Localization: | Nuclear, translocated into the nucleus in response to phosphorylation. |
| Background: | Signal Transducers and Activators of Transcription (STATs) are a family of cytoplasmic proteins that participate in cellular responses to cytokines and growth factors (1). Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases, and STATs are activated by tyrosine phosphorylation (2). Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including severe combined immunodeficiency and leukemia (4). STATs have been implicated in programming gene expression in biological events such as embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation in many organisms (3). STAT1 knockout mice are defective in interferon-mediated functions. STAT4 and STAT6 knockout mice show defective responses to IL-12 and IL-4, respectively. Analyses of STAT5a and STAT5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland (5). STAT6 and STAT4 are two STAT family members that specifically mediate signals from the IL-4 and IL-12 receptors, respectively (6). |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS with 0.1% sodium azide |
| ListPrice: | 285 |
| AppSummary: | IHC-Fr, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Signal transducer and activator of transcription 4 antibody, anti-STAT 4 antibody, anti-STAT-4 antibody |
| ProteinTarget: | STAT 4 |
| PackageSize: | 1 ml |
| GeneralRef: | General / background references:Wurster AL et al. The biology of Stat4 and Stat6. Oncogene 19:2577-84 (2000). Turkson J & Jove R STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19:6613-26 (2000). Ivashkiv LB Jak-STAT signaling pathways in cells of the immune system. Rev Immunogenet 2:220-30 (2000). Horvath CM STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 25:496-502 (2000). Nosaka T & Kitamura T Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) in hematopoietic cells. Int J Hematol 71:309-19 (2000). Takeda K & Akira S STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev 11:199-207 (2000). |
| NotesMain: | STATs are Signal Transducers and Activators of Transcription STATs are a family of cytoplasmic proteins that participate in cellular responses to cytokines and growth factors. Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases, and STATs are activated by tyrosine phosphorylation. Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including SCID and leukemia, and programming gene expression in biological events such as embryonic development, apoptosis, organogenesis, innate immunity, adaptive immunity and cell growth regulation. STAT1 knockout mice are defective in interferon-mediated functions. |
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