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| Catalog Code: | NB120-7491 |
| Product Name: | CD79a Antibody |
| Product Description: | Mouse Monoclonal anti-CD79a (HM47/A9) |
| Clone: | HM47/A9 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic polypeptide consisting of the amino acid sequence GTYQDVGSLNIADVQ. |
| Specificity: | This antibody is specific to human CD79a antigen complex, consisting of two polypeptides non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of polypeptide and immunoglobulins constitute the B cell antigen receptor. The two components of this complex are designated CD79a and CD79b. The CD79a antigen appears at the pre-B cell stage, early in maturation and persists until the plasma cell stage. The CD79a antigen is found in majority of acute leukemias of precursor B cell type, in B cell lines and B cell lymphomas. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 6 ml Purified Mouse IgG. |
| Uses: | IHC-P: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Background: | CD79a is a disulphide-linked heterodimer, consisting of CD79a / mb-1 and CD79b / B29 and is non-covalently associated with membrane-bound immunoglobulins on B cells to constitute the B cell antigen receptor. CD79a first appears at pre B cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas and in some myelomas. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Isotype: | IgG1 kappa |
| Host Name: | Mouse |
| Buffer: | Constituents: PBS |
| Application Summary: | immunohistochemistry-Fr, immunohistochemistry-P |
| Species Summary: | Hu |
| Alternate Names: | anti-B cell antigen receptor complex associated protein alpha chain precursor antibody, anti-B Lymphocyte Specific MB1 Protein antibody, anti-CD79A antigen immunoglobulin associated alpha antibody, anti-Ig alpha antibody, anti-IGA antibody, anti-Immunoglobulin Associated Alpha antibody, anti-Ly54 antibody, anti-MB1 membrane glycoprotein antibody |
| Package Size: | 6 ml |
| General References: | General / background references:Van Noesel CJ et al. Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers. J Exp Med 175:1511-9 (1992). |
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