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| Catalog Code: | NB120-7292 |
| Product Name: | Cystatin A Antibody |
| Product Description: | Mouse Monoclonal anti-Cystatin A (WR-23/2/3/3) |
| Clone: | WR-23/2/3/3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant full length protein (Human). |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.5 ml purified Mouse IgG. |
| Uses: | IHC-P: Use at a dilution of 1/50 - 1/100. Pretreatment with trypsin is required for paraffin sections.IHC-Fr: Use at a dilution of 1/50 - 1/100. We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic |
| Background: | Cystatins are endogenous inhibitors of lysosomal proteases that form a superfamily that is classified into three families (families 1,2 and 3) according to the homology of the amino acid sequences. Cystatin A (also termed acid cysteine proteinase inhibitor, ACPI, stefin A, and epidermal SH- proteinase inhibitor) belongs to family 1 of the cystatin superfamily of proteins. These proteins are natural inhibitors of cysteine proteinases like cathepsin B, H, L, and S. Cystatin A, a 98 amino acid protein (11-13 kDa), is detected in normal squamous epithelium, follicular dendritic cells in lymphoid tissues, thymic epithelial cells (in Hassall's corpuscles and in medulla), liver cells, granulocytes and basal epithelial cells in the prostate. Cystatin A is thought to be a tumor suppressor, since an inverse correlation seems to exist between the level of cystatin A and tumor progression, in several malignancies. Also, Cystatin A has been implicated in aging of tissues, Alzheimer disease, viral infections and inflammatory processes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Preservative: Sodium Azide Constituents: PBS, BSA |
| Application Summary: | immunohistochemistry-Fr, immunohistochemistry-P |
| Species Summary: | Hu |
| Alternate Names: | anti-CSTA antibody, anti-CSTA protein antibody, anti-Cystatin A antibody, anti-Cystatin AS antibody, anti-CystatinA antibody, anti-Stefin A antibody, anti-Stefin A1 antibody, anti-StefinA antibody, anti-STF 1 antibody, anti-STF1 antibody, anti-STFA antibody |
| Package Size: | 0.5 ml |
| General References: | 1. Kuopio, T., et al. Cancer Res. 58, 432, (1998) |
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