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| Catalog Code: | NB120-6407 |
| Product Name: | CD2 Antibody |
| Product Description: | Mouse Monoclonal anti-CD2 (OX34) |
| Clone: | OX34 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 1.0 mg/ml |
| Immunogen: | Activated rat T helper cells |
| Specificity: | Recognizes a determinant expressed on thymocytes and peripheral T cells. It does not bind to B cells or peritoneal macrophages. |
| Cross Reactivity: | Cross-reacts with Rat.Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse IgG. |
| Uses: | FACS: Use at a dilution of 1/400. IHC: Use at a dilution of 1/400. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane protein. |
| Background: | CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin. |
| Storage: | Store at +4oC or at -20oC if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we r |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline pH7.4 |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry |
| Species Summary: | Rt, |
| Alternate Names: | anti-LFA2 antibody, anti-LFA3 receptor antibody, anti-Lymphocyte function antigen 2 antibody, anti-p50 antibody, anti-Rosette receptor antibody, anti-Sheep erythrocyte receptor antibody, anti-Sheep red blood cell receptor antibody, anti-SRBC antibody, anti-T cell surface antigen CD2 antibody, anti-T cell surface antigen T11/Leu 5 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| General References: | General / background references:Whiteland JL et al. Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. J Histochem Cytochem 43:313-20 (1995). Beyers AD et al. Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen. Immunol Rev 111:59-77 (1989). Williams AF et al. Similarities in sequences and cellular expression between rat CD2 and CD4 antigens. J Exp Med 165:368-80 (1987). Jefferies WA et al. Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages. J Exp Med 162:117-27 (1985). Barclay AN Different reticular elements in rat lymphoid tissue identified by localization of Ia, Thy-1 and MRC OX 2 antigens. Immunology 44:727-36 (1981). |
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