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| Catalog Code: | NB120-6280 |
| Product Name: | Cdc25A Antibody |
| Product Description: | Mouse Monoclonal anti-Cdc25A (DCS 121) |
| Clone: | DCS 121 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Recombinant full length protein. |
| Specificity: | Recognizes human Cdc25A, a 65kD protein phosphatase which plays an important role in cell cycle regulation. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Mouse ascites. |
| Uses: | Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| Background: | CDC25A, a CDC25 dual specificity protein phosphatase, has been shown to activate the cyclin-dependent kinases at different points of the cell cycle. CDC25A has been shown to affect S phase entry and possibly the initiation of mitosis. CDC25A dephosphorylates cyclin dependent kinases, including Cdk2, Cdk4, as well as non cyclin proteins such as the homeodomain transcription factor cut, the proto-oncogene Raf-1. CDC25A has been implicated in many carcinomas, including those of the colon, lymph node, stomach, ovary, breast. CDC25A is located on chromosome 3p21 in an area frequently involved in karyotypic abnormalities in renal carcinomas, small cell carcinomas of the lung, and benign tumors of the salivary gland. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2a |
| Host Name: | Mouse |
| Buffer: | PBS + 0.08% Sodium Azide (NaN3) |
| Application Summary: | immunoprecipitation, Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-Cell division cycle 25A isoform a antibody, anti-Cell division cycle 25A isoform b antibody, anti-Dual specificity phosphatase CDC25A antibody, anti-M phase inducer phosphatase 1 antibody |
| Package Size: | 0.05 mg |
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more information: | company product webpage |