| CatalogCode: | NB120-6228 |
| ProductName: | Thyroglobulin Antibody |
| Product Description: | Mouse Monoclonal anti-Thyroglobulin (TGB04) |
| Clone: | TGB04 |
| Clonality: | Monoclonal |
| Immunogen: | BALB/C mice were injected with purified human thyroglobulin. |
| Specificity: | This antibody is specific to 330 kD protein. |
| CrossReactivity: | Cross-reacts with Dog, Human, Mouse and Rat. Not yet tested in other species. |
| Packaging: | 0.5 ml Mouse ascites. |
| Uses: | IHC-P: Use at an assay dependent dilution. IHC-Fr: Use at an assay dependent dilution. For formalin fixed paraffin embedded sections no special pre-treatment is required. |
| Localization: | Secreted |
| Control: | Thyroid. |
| Background: | Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin is the glycoprotein precursor to the thyroid hormones. Its synthesis and metabolism have seemingly wasteful features. It has a molecular weight of 660,000, with 2 identical subunits of MW 300,000 and 10% sugars; yet its complete hydrolysis yields only 2 to 4 molecules of the iodothyroxines T4 and T3. Baas et al. (1986) showed that the TG gene encodes an 8.7-kb mRNA, covers at least 300 kb of genomic DNA and contains at least 37 exons separated by introns as large as 64 kb. A striking structural difference between the 5-prime and 3-prime parts of the gene suggested that it is composed of 2 evolutionarily different regions. The first 30 kb of DNA encodes 3 kb of the mRNA yielding an exon:intron ratio of 1:10, whereas the remaining 270 kb encodes 5.7 kb of the mRNA with a ratio of 1.47. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Constituents: PBS |
| ListPrice: | 285 |
| AppSummary: | IHC, IHC-P, IHC-Fr |
| SpeciesSummary: | Ca, Hu, Mu, Rt |
| ALTnames: | anti-AITD3 antibody, anti-hTG antibody, anti-Tgn antibody |
| ProteinTarget: | Thyroglobulin |
| PackageSize: | 0.5 ml |
| GeneralRef: | General / background references:Skalli O et al. Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest 60:275-85 (1989). Baas F et al. The human thyroglobulin gene is over 300 kb long and contains introns of up to 64 kb. Nucleic Acids Res 14:5171-86 (1986). Skalli O et al. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 103:2787-96 (1986). |
| NotesMain: | Thyroglobulin antibody has been useful in the positive identification of thyroid carcinomas of the papillary and follicular types. |
order or
more information: | company product webpage |
| request information: |
|