| CatalogCode: | NB120-5992 |
| ProductName: | PHAP1 Antibody |
| Product Description: | Rabbit Polyclonal anti-PHAP1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human).(intermediate domain) |
| Specificity: | This antibody does not cross-react with PHAP12a or PHAPIII. |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | WB: Use at a concentration of 0.5 - 2.0 ug/ml. Detects a band of approximately 32 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cytoplasmic and Nuclear |
| Control: | Raji whole cell lysate. |
| Background: | Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and ?7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-mediated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-mediated cell transformation. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Preservative: 0.02% Sodium AzideConstituents: PBS |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | PHAP1 |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Jiang X et al. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science 299:223-6 (2003). Nicholson DW & Thornberry NA Apoptosis. Life and death decisions. Science 299:214-5 (2003). |
| NotesMain: | Stable for one year. |