| CatalogCode: | | NB120-5991 |
| ProductName: | | PHAP1 Antibody |
| Product Description: | | Rabbit Polyclonal anti-PHAP1 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide (Human). |
| Specificity: | | This antibody does not cross react with PHAP12a or PHAPIII isoforms. |
| CrossReactivity: | | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | | 0.05 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | | WB: Use at a concentration of 0.5 - 2.0 ug/ml. Detects a band of approximately 32 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Cytoplasmic and Nuclear |
| Control: | | Raji whole cell lysate. |
| Background: | | Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and ?7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-mediated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-mediated cell transformation. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | Preservative: 0.02% Sodium AzideConstituents: PBS |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu, Mu, Rt |
| ProteinTarget: | | PHAP1 |
| PackageSize: | | 0.05 mg |
| GeneralRef: | | General / background references:Jiang X et al. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science 299:223-6 (2003). Nicholson DW & Thornberry NA Apoptosis. Life and death decisions. Science 299:214-5 (2003). |
| NotesMain: | | Stable for one year. |
| more information: | | company product webpage |