| CatalogCode: | NB120-5800 |
| ProductName: | NCoR2 Antibody |
| Product Description: | Rabbit Polyclonal anti-NCoR2 |
| Clonality: | Polyclonal |
| Immunogen: | Purified His-tagged fusion protein, corresponding to amino acids 1302-1495 of Human NCoR2. |
| Specificity: | NB120-5800 detects silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) from human tissues. |
| CrossReactivity: | Cross-reacts with Human and Mouse (see review).Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit IgG. |
| Uses: | IP: Use at an assay dependent dilution. WB: Use at a concentration of 2 ug/ml. Detects a band of approximately 250 kDa (predicted molecular weight: 300 kDa) representing SMRT from HeLa cell nuclear extracts. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | ChIP, IP, WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-CTG26 antibody, anti-SMRT antibody, anti-SMRTE antibody, anti-SMRTE-tau antibody, anti-TNRC14 antibody, anti-TRAC-1 antibody, anti-TRAC1 antibody |
| ProteinTarget: | NCoR2 |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Ordentlich P et al. Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A 96:2639-44 (1999). Li H et al. Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol 11:2025-37 (1997). |
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