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| Catalog Code: | NB120-5628 |
| Product Name: | Kinesin 5A Antibody |
| Product Description: | Rabbit Polyclonal anti-Kinesin 5A |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Concentration: | 1 mg/ml |
| Immunogen: | Synthetic peptide: CGYEAEDQAKLFPLHQETAAS, corresponding to amino acids 1007-1027 of Mouse Kinesin 5A, this sequence is completely conserved in human. |
| Specificity: | This antibody is specific for kinesin 5A and does not detect other kinesin isotypes. |
| Cross Reactivity: | Cross-reacts with Cow, Human and Mouse.Expected to cross-react with Rat (95% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit IgG. |
| Uses: | WB: Use at a concentration of 0.4 ug/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 117 kDa) representing kinesin 5A from mouse neuronal cell lysate and human retinal extracts.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Concentrated in the cell body of the neurons, particularly in the perinuclear region. |
| Background: | Kinesins are a superfamily of microtubule-associated motor proteins involved in a variety of cellular processes including membranous organelle transport and cell division. Kinesin has been found in a variety of organisms and cell types and is subject to spatial and temporal regulation. These proteins have a modular structure including a conserved motor domain of approximately 350 amino acids, which is responsible for microtubule binding and ATP hydrolysis. In addition to the motor domain, subfamily members share common domain organization, exhibit sequence similarity, motility properties, and cellular functions outside of the motor domain. There are currently three known Kinesin 5 family members denoted as A, B, and C. Kinesin 5A and kinesin 5C appear to be exclusively neuronal, whereas kinesin 5B appears to be ubiquitous in its expression. |
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Western Blot 0.4 ug/ml |
| Species Summary: | Bv, Hu, Mu, |
| Alternate Names: | anti-KIF 5A antibody, anti-KIF5A antibody, anti-Kinesin Heavy Chain Neuron Specific antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.05% Sodium Azide, 1mg/ml BSA |
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