| CatalogCode: | NB120-5593 |
| ProductName: | Leptin Receptor Antibody |
| Product Description: | Rabbit Polyclonal anti-Leptin Receptor |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: KEIQWKTHEVFDAKSKSA, corresponding to amino acids 577-594 of Rat leptin receptor. |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit antisera. |
| Uses: | WB: Detects bands of approximately 100 and 125 kDa, corresponding to the long and short forms (respectively) of leptin receptor OB-R from mouse brain extract. Two smaller bands of approximately 31 and 35 kDa are also detected, which cannot be competed out with immunogenic peptide. |
| Localization: | Type I membrane protein. Except for form E which could be soluble. |
| Control: | Mouse brain extract. |
| Background: | Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Constituents: PBS |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-obl antibody, anti-CD 295 antibody, anti-CD295 antibody, anti-CD295 antigen antibody, anti-Db antibody, anti-Fa antibody, anti-HuB219 antibody, anti-LEP R antibody, anti-LEPR antibody, anti-LEPROT antibody, anti-Leptin receptor fatty antibody, anti-Leptin receptor gene related protein antibody, anti-Leptin receptor precursor antibody, anti-OB R antibody, anti-OB R gene related protein antibody, anti-OB receptor antibody, anti-OB-RGRP antibody, anti-Obr antibody |
| ProteinTarget: | Leptin Receptor |
| PackageSize: | 0.1 ml |
| GeneralRef: | General / background references:Harris RB et al. Metabolic responses to leptin in obese db/db mice are strain dependent. Am J Physiol Regul Integr Comp Physiol 281:R115-32 (2001). Tartaglia LA et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-71 (1995). |
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