| CatalogCode: | NB120-54418 |
| ProductName: | Adenine Nucleotide Translocase 1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Adenine Nucleotide Translocase 1 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide corresponding to amino acids 2-11 of human ANT-1. |
| Specificity: | Recognizes a band at approximately 35 kDa. |
| CrossReactivity: | Cross-reacts with Human. Expected to cross-react with Rhesus Monkey due to sequence homology. |
| Packaging: | 0.1 mg Whole antisera Rabbit antisera. |
| Control: | Doxorubicin treated MCF7 cells, human breast carcinoma |
| Background: | Adenine Nucleotide Translocase 1 (ANT1) catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. It is is a key component of the mitochondrial permeability transition pore (PT pore) complex and is also one of the most abundant proteins in the mitochondrion making up approximately 10% of all mitochondrial proteins. Originally described as an ADP/ATP exchange factor, ANT1 has also been shown to be required for bax mediated apoptosis. This is effected by binding of bax to residues 105-156 of ANT1, presumably resulting in maintaining the PT pore in an open conformation. Interaction with bax is not required for ANT1 pro-apoptotic activity as overexpression of the ANT1 protein also leads to the induction of apoptosis. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM sodium phosphate buffer, 50% glycerol. |
| ListPrice: | 325 |
| AppSummary: | IF, WB, ICC, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-ANT-1 antibody, anti-ANT1 antibody |
| PackageSize: | 0.1 mg |
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