| Catalog Code: | NB120-4717 |
| Product Type: | Primary Antibody |
| Product Name: | c-Abl Antibody |
| List Price: | 330 |
| Clonality: | Polyclonal |
| Gene ID: | 25 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-c-Abl [Tyr412] |
| Phosphorylated: | Tyr412 |
| Cross Reactivity: | Cross-reacts with Human.Expected to cross-react with Mouse (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | c-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human c-Abl 1b that contains tyrosine 412. Note: there are two widely expressed forms of c-Abl produced by alternative splicing, designated 1b (the more co |
| Localization: | Cytoplasmic and Nuclear |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.05% Sodium AzideConstituents: PBS (without Mg2+ and Ca2+), 1.0mg/ml BSA (IgG, protea |
| Packaging: | 50 microlitres |
| Package Size: | 0.05 ml |
| Uses: | WB: Use at a concentration of 0.1 - 1.0 ug/ml. Detects a band of approximately 140 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Application Summary: | WB |
| General References: | General / background references:Cong F et al. Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase. J Biol Chem 277:34870-8 (2002). Furstoss O et al. c-Abl is an effector of Src for growth factor-indu |