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| Catalog Code: | NB120-4061 |
| Product Name: | ALK Antibody |
| Product Description: | Rabbit Polyclonal anti-ALK |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the c-terminus of the NPM-Alk transcript. |
| Specificity: | This antibody reacts with an 80 kDa protein. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.5 ml IgG purified Rabbit antisera. |
| Uses: | Immunohistochemistry paraffin and frozenOptimal working dilutions should be determined by end user. |
| Localization: | Cell Membrane |
| Background: | Anaplastic lymphoma kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. ALK and LTK (leukocyte tyrosine kinase) are receptor tyrosine kinases similar to the insulin receptor subfamily of kinases. LTK is found in murine B Lymphocyte precursors and in forebrain neurons. ALK is usually found in the nervous system. A truncated form of ALK occurs in many non Hodgkin's lymphomas. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 [t(2;5}], the ALK gene fuses with the NPM gene. NPM, also known as B23, is an ubiquitous nucleolar phosphoprotein involved in the transport of pre ribosomal components between the nucleolus and the cytoplasm. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK. Karpas 299 and SUDHL1 lymphoid cell lines strongly express NPM ALK. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | immunohistochemistry 1:50 - 1:100, Immunohistochemistry-Paraffin 1:50 - 1:100, Immunohistochemistry-Frozen 1:50 - 1:100 |
| Species Summary: | Hu, |
| Alternate Names: | anti-ALK tyrosine kinase receptor antibody, anti-ALK Tyrosine Kinase Receptor Precursor antibody, anti-Anaplastic lymphoma kinase Ki 1 antibody, anti-Anaplastic lymphoma kinase Ki1 antibody, anti-Anaplastic Lymphoma Kinase p80 antibody, anti-CD 246 antibody, anti-CD246 antibody, anti-CD246 Antigen antibody, anti-Ki 1 antibody, anti-Ki1 antibody, anti-TFG/ALK antibody |
| Package Size: | 0.5 ml |
| Preservative: | sodium azide |
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more information: | company product webpage |