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| Catalog Code: | NB120-3570 |
| Product Name: | Cytochrome P450 2A6 Antibody |
| Product Description: | Rabbit Polyclonal anti-Cytochrome P450 2A6 |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Concentration: | 1 mg/ml |
| Immunogen: | Purified His-tagged full length human P450 2A6 fusion protein. |
| Specificity: | Detects cytochrome P450 2A6 from human and rat tissues and cells. This antibody detects, to a lesser extent, other P450 isoforms. |
| Cross Reactivity: | Cross-reacts with Human and Rat.Not yet tested in other species. |
| Packaging: | 0.1 ml IgG purified Rabbit IgG. |
| Uses: | Western blot: use at a dilution of 1/2000.Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects an ~49 kDa protein representing P450 2A6 from rat liver extract. |
| Localization: | Endoplasmic reticulum membrane; Peripheral membrane protein. |
| Background: | The Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Western Blot 1:2,000 |
| Species Summary: | Hu, Rt, |
| Alternate Names: | anti-CPA6 antibody, anti-Coumarin 7 hydroxylase antibody, anti-CYP2A3 antibody, anti-CYPIIA6 antibody, anti-P450 IIA3 antibody, anti-P450(I) antibody, anti-CYP2A antibody, anti-CYP2A6 antibody, anti-Cytochrome P450 2A6 antibody, anti-Cytochrome P450, family 2, subfamily A, polypeptide 6 antibody, anti-P450C2A antibody, anti-P450PB antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.05% sodium azide |
| General References: | General / background references:Oscarson M et al. Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase. FEBS Lett 438:201-5 (1998). Honkakoski P & Negishi M The structure, function, and regulation of cytochrome P450 2A enzymes. Drug Metab Rev 29:977-96 (1997). |
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more information: | company product webpage |