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| Catalog Code: | NB120-3569 |
| Product Name: | Cytochrome P450 1A2 Antibody |
| Product Description: | Rabbit Polyclonal anti-Cytochrome P450 1A2 |
| Clonality: | Polyclonal |
| ListPrice: | 285 |
| Immunogen: | Purified His-tagged full length human P450 1A2 fusion protein. |
| Specificity: | Detects Cytochrome P450 1A2 from human cells as well as recombinant human P450 1A2. This antibody detects, to a lesser extent, other P450 isoforms. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 ml IgG purified Rabbit IgG. |
| Uses: | Western blot: use at a dilution of 1/1000.Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects an ~56 kDa protein representing recombinant human P450 1A2. |
| Localization: | Endoplasmic reticulum membrane; Peripheral membrane protein. |
| Background: | The Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | Western Blot 1:1,000 |
| Species Summary: | Hu, |
| Alternate Names: | anti-Aryl hydrocarbon hydroxylase antibody, anti-CP 12 antibody, anti-CP12 antibody, anti-CYP1A2 antibody, anti-CYPIA2 antibody, anti-Cytochrome P450 family 1 polypeptide 2 antibody, anti-Cytochrome P450 family 1 subfamily A polypeptide 2 antibody, anti-Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2 antibody, anti-Cytochrome P4501A2 antibody, anti-Dioxin inducable P3 450 antibody, anti-Flavoprotein linked monooxygenase antibody, anti-Microsomal monooxygenase antibody, anti-P(3)450 antibody, anti-P3 450 antibody, anti-P450 4 antibody, anti-P450 form 4 antibody, anti-P450 P3 antibody, anti-P450(PA) antibody, anti-Xenobiotic monooxygenase antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.05% sodium azide |
| General References: | General / background references:Gonzalez FJ The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption. Toxicol Lett 102-103:161-6 (1998). Brosen K Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet 29 Suppl 1:20-5 (1995). |
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