| CatalogCode: | NB120-3473 |
| ProductName: | KChIP 2 Antibody |
| Product Description: | Rabbit Polyclonal anti-KChIP 2 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic Peptide: R(6)KESLSDSRDLDGSYDQLT(24)C. Synthetic peptide corresponds to amino acid residues 6-24 from human KChIP 2. This sequence is completely conserved in mouse and rat. |
| Specificity: | Detects KChIP 2 b and c from rat and rabbit samples as well as recombinant rat KChIP 2c. This antibody does not detect KChIP 2a. |
| CrossReactivity: | Cross-reacts with Human, Rabbit and Rat.Expected to cross-react with Mouse due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit IgG. |
| Uses: | Western Blot: use at a concentration of 2 ug/ml.Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects ~33 and 26 kDa proteins representing KChIP2b and c, respectively, from rat ventricular myocyte whole cell lysate. |
| Localization: | Cell Membrane; Lipid-anchor (By similarity). |
| Background: | Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function.There are currently three known KChIPs; KChIP 1 expressed in the brain; KChIP 2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP 3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Rb, Rt |
| ALTnames: | anti-A type potassium channel modulatory protein 2 antibody, anti-Cardiac voltage gated potassium channel modulatory subunit antibody, anti-DKFZp566L1246 antibody, anti-KChIP 2 antibody, anti-KCNIP 2 antibody, anti-KCNIP2 antibody, anti-Kv channel interacting protein 2 antibody, anti-MGC17241 antibody, anti-Potassium channel interacting protein 2 antibody |
| ProteinTarget: | KChIP 2 |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Jo DG et al. Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J 15:589-91 (2001). Rosati B et al. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533:119-25 (2001). An WF et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403:553-6 (2000). |